Nope, not loading via any other software. I'll check the profile issue but this is a fresh OS install (not saying it can't happen though). It's odd that it only happens in ImgBurn though. I'm not sure which other apps I have store settings in the registry but I'm sure there's at least a few.
At first I thought I was going mad but alas it's a small bug. My settings (i.e. Disable sounds) are still present if I close and restart the program. However they are lost after a reboot.
p.s. Thanks for the best damn burning app there is, free or paid.