I'm not really sure what you're saying but the queue only works for images.
You can queue stuff you'd normally burn in Build mode.
Well, all you could do is build the ISO's and then queue them up.
If you need to burn an ISO file twice via the queue to two different drives, obvioulsy you don't need 2 copies of that file, you just add the same one to the queue again but tell it to use a different drive for burning.